Magnetic Resonance Elastography and Portal Hypertension: Influence of the Portal Venous Flow on the Liver Stiffness

The invasive measurement of the hepatic venous pressure gradient is still considered as reference method to assess severity portal hypertension. Even though previous studies have shown that liver stiffness measured by elastography could predict hypertension in patients with chronic disease, mechanisms behind remain today poorly understood. main reason not specific and also influenced concomitant pathologies, such cirrhosis. Portal source a vascular incidence, substantial diversion blood systemic circulation, bypassing liver. This study focuses on this effect We propose generate control flow (to isolate modifications single hypertension) an anesthetized pig then quantify its implications original combination MRE 4D-Flow Magnetic Resonance Imaging (MRI). A catheter balloon progressively inflated vein peak flow, velocity magnitude are quantified 1.5T MRI scanner (AREA, Siemens Healthcare, Erlangen, Germany). strong correlation observed between magnitude, or intraluminal obstruction. Moreover, comparison mechanical parameters highlights possibility identifying linear relationships. These results give preliminary indications about how can be affected and, extension,